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Adaptive tolerance to a pathogenic fungus drives major histocompatibility complex evolution in natural amphibian populations [Proceedings of the Royal Society B]

Keywords : major histocompatibility complex, amphibian, chytridiomycosis, {Batrachochytrium dendrobatidis}, immunogenetics, adaptation

par Frédéric Magné - publié le

Amphibians have been affected globally by the disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), and we are just now beginning to understand how immunogenetic variability contributes to disease susceptibility. Lineages of an expressed major histocompatibility complex (MHC) class II locus involved in acquired immunity are associated with chytridiomycosis susceptibility in controlled laboratory challenge assays. Here, we extend these findings to natural populations that vary both in exposure and response to Bd.(...)

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