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An Individual-Centered Framework For Unravelling Genotype-Phenotype Interactions [Trends in Ecology & Evolution]

Keywords : genome, epigenome, proteome, phenome, syndrome, molecular pedigree of evolutionary changes

par Frédéric Magné - publié le

A new framework in which the multiple levels of molecular variations contribute to phenotypic variations in a complex, nonlinear and interactive way, challenges the hierarchical nature of the relationships between the genotypic and phenotypic spaces. This individual-centered framework provides new insights on the evolutionary mechanisms involved in the production of phenotypes. We propose to move this research agenda forward by combining selection experiments and functional genetics.

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