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An orphan gene is necessary for preaxial digit formation during salamander limb development [Nature communications]

keywords : biological sciences, developmental biology, evolution

par Frédéric Magné - publié le

Limb development in salamanders differs from other tetrapods in that the first digits to form are the two most anterior (preaxial dominance). This has been proposed as a salamander novelty and its mechanistic basis is unknown. Salamanders are the only adult tetrapods able to regenerate the limb, and the contribution of preaxial dominance to limb regeneration is unclear.(...)

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