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Tetrapod limb and sarcopterygian fin regeneration share a core genetic programme [Nature Communications]

Keywords : evolutionary developmental biology, regeneration, transcriptomics

par Frédéric Magné - publié le

Salamanders are the only living tetrapods capable of fully regenerating limbs. The discovery of salamander lineage-specific genes (LSGs) expressed during limb regeneration suggests that this capacity is a salamander novelty. Conversely, recent paleontological evidence supports a deeper evolutionary origin, before the occurrence of salamanders in the fossil record. Here we show that lungfishes, the sister group of tetrapods, regenerate their fins through morphological steps equivalent to those seen in salamanders.(...)

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